Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats
by Lei Zhang, Xue-Jun Sun, Yan-Fei Mao, Jian Mei Cai, John H.l Jiang, Xiao-Meng Deng, Xin-Min You, Xing-Feng Zheng
Abstract:
Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats. Male Sprague-Dawley rats (n=30, 200-220g) were divided randomly into three experimental groups: sham operated, intestinal I/R plus saline treatment (5ml/kg, i.v.), and intestinal I/R plus hydrogen-rich saline treatment (5ml/kg, i.v.) groups. Intestinal I/R was produced by 90min of intestinal ischemia followed by a 4h of reperfusion. Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat. Hydrogen-rich saline attenuates lung injury induced by intestinal I/R.
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https://doi.org/10.1016/j.bbrc.2009.02.105
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