Suppressive Effect of Electrolyzed-Reduced Water on the Growth of Cancer Cells and Microorganisms
by Shigeru Kabayama, Kiichiro Teruya, Sanetaka Shirahata, Shinkatsu Morisawa, Takaaki Komatsu, Yoshinori Katakura, Akira Hayashida, Hirofuma Nogami, Kazumiti Otsubo
Abstract:
We investigated the suppressive effect of electrolyzed reduced water (ERW) on the growth of not only various human cancer cells but also microorganisms such as gram-negative Escherichia coli. ERW suppressed the growth of cancer cells, especially in soft-agar culture. The suppressive effect of ERW on the growth of cancer cells depended upon cell types and malignancy of cancer cells and the production methods of ERW. We assumed that scavenging intracellular reactive oxygen species (ROS) by ERW resulted in impairing the tumor phenotypes such as rapid proliferation and anchorage-independent growth without affecting serious damage to normal cells. We also found that ERW exhibited weak microbicidal effect, especially in low cell densities of microorganisms. It may contribute to prevent the rot of food or improve the intestinal microflora to prevent abnormal fermentation.
Read more:
https://doi.org/10.1007/978-94-010-0369-8_50
Related Articles:
The poor penetration of nanocarriers within tumor dense extracellular matrices (ECM) greatly restricts the access of anticancer drugs to the deep tumor cells, resulting in low therapeutic efficacy. Moreover, the high toxicity of the traditional chemotherapeutics inevitably causes undesirable side…
Aims: Doxorubicin is a drug widely used in clinical cancer treatment, but severe cardiotoxicity limits its clinical application. Autophagy disorder is an important factor in the mechanism of doxorubicin-induced cardiac injury. As the smallest molecule in nature, hydrogen has various…
Background: Ocular melanoma is a rare kind of eye malignancy that threatens the patient’s eyesight. Radiotherapy and surgical removal are the most commonly used therapeutic modalities, and nanomedicine has lately entered this field. Brachytherapy using Ruthenium-106 (106 Ru) ophthalmic plaques…
Combination therapy is an emerging strategy to overcome multidrug resistance (MDR) in hepatocellular carcinoma (HCC) chemotherapy treatment. However, the passive diffusion in traditional delivery systems greatly retards the approach and penetration of drugs into hepatocellular carcinoma cells and thus hinders…
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular…
Molecular hydrogen ameliorates pathological states in a variety of human diseases, animal models, and cell models, but the effects of hydrogen on cancer have been rarely reported. In addition, the molecular mechanisms underlying the effects of hydrogen remain mostly unelucidated….






0 Comments