Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake and the diminished normal-cell mortality
by Nobuhiko Miwa, Shinya Kato, Yasukazu Saitoh
Abstract:
Carcinostatic effects of combined use of hydrogen nano-bubbles (nano-H) and platinum–povidone (PVP-–Pt) were examined. Hydrogen-dissolved medium was prepared by hydrogen-gas bubbling with a microporous gas-emittance-terminal into a medium in the absence or presence of PVP–Pt (nano-H, nano-H/PVP–Pt). Human esophagus-derived carcinoma cells KYSE70 were repressed for cell proliferation with nano-H/PVP–Pt more markedly than with nano-H, indicating the hydrogen-intensification for PVP–Pt-alone-carcinostasis. However, the intensified carcinostasis required co-administration of nano-H and PVP–Pt, and no intensified carcinostasis was shown in two-step separate administration of nano-H and PVP–Pt. Furthermore, hydrogen bubbling into PVP–Pt-containing medium achieved more appreciable carcinostasis than mere addition of PVP–Pt into nano-H-containing medium, indicating the potent interaction of hydrogen and PVP–Pt. The nano-H/PVP–Pt-administered human tongue-derived carcinoma cells HSC-4 were repressed for cell proliferation more markedly than pre-malignant human tongue-derived epitheliocytes DOK, concurrently with more abundant intracellular Pt-intake into HSC-4 cells than DOK as analyzed by ICP-MS. Thus, PVP–Pt is able to adsorb hydrogen nano-bubbles on Pt and applicable for cancer therapy by diminishing the side-effects to normal cells.
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https://doi.org/10.1007/s13577-020-00402-1
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