Biodegradable Mg Implants Suppress the Growth of Ovarian Tumor
by Yongjie Wang, Hongzhou Peng, Jiahua Ni, Rui Zan, Xiaonong Zhang, Yu Sun, Yang Song, Hongliu Wu, Rui Zhang, Shaoxiang Zhang, Shuang Qiao
Abstract:
The common treatment of epithelial ovarian cancer is aggressive surgery followed by platinum-based cytotoxic chemotherapy. However, residual tumor cells are resistant to chemotherapeutic drugs during postoperative recurrence. The treatment of ovarian cancer requires new breakthroughs and advances. In recent years, magnesium alloy has been widely developed as a new biodegradable material because of its great potential in the field of medical devices. From the degradation products of magnesium, biodegradable magnesium implants have great potential in anti-tumor. According to the disease characteristics of ovarian cancer, we choose it to study the anti-tumor characteristics of biodegradable magnesium. We tested the anti-ovarian tumor properties of Mg through both in vivo and in vitro experiments. According to the optical in vivo imaging and relative tumor volume statistics of mice, high-purity Mg wires significantly inhibited the growth of SKOV3 cells in vivo. We find that the degradation products of Mg, Mg2+ and H2, significantly inhibit the growth of SKOV3 cells and promote their apoptosis. Our study suggests a good promise for treatment of ovarian cancer.
Read more:
https://doi.org/10.1021/acsbiomaterials.9b01703
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