Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine
by Alexis R. Cole, John N. Kheir, Ali Raza, Allen D. Everett, Arthur P. Nedder, Brenda Sefton, Brian D. Polizzotti, Daniel Davila, Dorothy A. Perry, Edward Yang, Elizabeth Pollack, Hart G.W. Lidov, Jeffrey J. Neil, John E. Mayer, Onur Afacan, Sarah J. van den Bosch, Simon K. Warfield, William L. Regan, Yangming Ou
Abstract:
Highlights • Inhaled hydrogen gas has been shown to temper the sequelae of ischemic insults. Its application in cardiopulmonary bypass has not been investigated. • Neonatal swine were cannulated to cardiopulmonary bypass and exposed to prolonged circulatory arrest (75 min at 25°C). Swine were randomized to treatment with or without inhaled 2.4% hydrogen gas mixtures for 24 h during and following ischemic injury. Hydrogen-treated swine exhibited significantly less severe brain injury than controls, as quantified by clinical examination, serology, magnetic resonance-graded volume of injury, and histopathology. Hydrogen treatment also decreased renal injury. • The administration of inhaled 2.4% hydrogen gas mixtures through a standard ventilator and anesthesia machine were safe, even in the setting of electrocautery.
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https://doi.org/10.1016/j.jacbts.2018.11.006
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