Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats
by Jing Yang, Liqun Zhu, Lu Fu, Shujing Wu, Zhixin Fan, Jingjing Cai, Rui Luan, Yanli Dong
Abstract:
Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.
Read more:
https://doi.org/10.1691/ph.2014.3859
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